Build My Longevity.
United States · Longevity research

Monitoring the science

It's worth keeping an eye on scientific studies that might shape the advice medical experts provide, and help you get educated to build your own approach to longevity.

6 studies covered · PubMed-sourced, peer-reviewed only · last updated Sep 25, 2026

Six studies, checked and sourced

Peer-reviewed only — no preprints, no press releases. Each entry links directly to the paper on PubMed. Not medical advice: these are factual summaries of what a study found, not a recommendation for what you should do.

Large human study Exercise

Your fitness level predicts survival better than almost anything else doctors measure

Tracking 122,007 adults referred for treadmill testing at the Cleveland Clinic, researchers found the least fit had a death rate on par with major chronic diseases — while the fittest kept seeing benefits with no upper limit.

Added Sep 10, 2026
Study
Association of Cardiorespiratory Fitness With Long-term Mortality Among Adults Undergoing Exercise Treadmill Testing
Journal
JAMA Network Open, Oct 19, 2018
Design
Retrospective cohort, 122,007 adults, Cleveland Clinic exercise-testing database (1991–2014)
Authors
Mandsager K, Harb S, Cremer P, Phelan D, Nissen SE, Jaber W
Large human study Sleep

A consistent bedtime may matter more than hitting 8 hours

Tracking sleep patterns in 60,977 UK adults over 7 years, researchers found how regular your sleep schedule is predicted death risk more strongly than how many hours you actually slept.

Added Sep 10, 2026
Study
Sleep regularity is a stronger predictor of mortality risk than sleep duration: A prospective cohort study
Journal
Sleep, Jan 2024 (Vol 47, Issue 1, zsad253)
Design
Prospective cohort, 60,977 adults with valid actigraphy data, UK Biobank (1,859 deaths over follow-up)
Authors
Windred DP, Burns AC, Lane JM, Saxena R, Rutter MK, Cain SW, Phillips AJK
Human trial Diet

Eating in an 8-hour window didn't beat plain calorie counting

In a year-long trial of 139 adults with obesity, restricting eating to 8am–4pm plus calorie restriction produced statistically similar weight loss, waist circumference and blood-marker results to calorie restriction alone.

Added Sep 10, 2026
Study
Calorie Restriction with or without Time-Restricted Eating in Weight Loss
Journal
New England Journal of Medicine, Apr 21, 2022 (Vol 386, No 16)
Design
Randomized controlled trial, 139 adults with obesity, 12 months, Guangzhou, China
Authors
Liu D, Huang Y, Huang C, Yang S, Wei X, Zhang P, et al.
Review of existing research Supplements

Creatine helps older adults hold onto muscle — but only alongside training, not instead of it

Pooling 11 randomized trials in adults 60+, creatine added a modest but real strength benefit on top of resistance training. The effect size was small — training was still doing most of the work.

Added Sep 10, 2026
Study
Effects of resistance training combined with creatine supplementation on muscle strength, physical function, and muscle mass in older adults: a systematic review and three-level meta-analysis
Journal
Frontiers in Nutrition, 2026 (Vol 13)
Design
Systematic review & three-level meta-analysis, 11 RCTs, adults 60+ (effect size g = 0.31 for strength vs. resistance training alone)
Animal study Longevity drugs

Clearing "zombie cells" extended survival in aged mice — human evidence is still early

A two-drug combination that clears senescent ("zombie") cells improved physical function and extended post-treatment survival by 36% in naturally aged mice. It's a mouse study — nothing yet shows the same longevity effect in people.

Added Sep 10, 2026
Study
Senolytics improve physical function and increase lifespan in old age
Journal
Nature Medicine, Aug 1, 2018 (Vol 24, pages 1246–1256)
Design
Preclinical, naturally aged and senescent-cell-transplanted mice, Mayo Clinic — not a human trial
Authors
Xu M, Pirtskhalava T, Farr JN, Weigand BM, Palmer AK, Weivoda MM, et al.
Human trial Brain health

A coached lifestyle program protected thinking skills a bit better than going it alone

In 2,111 at-risk US adults aged 60–79, two years of structured exercise, MIND-style diet, brain training and regular group check-ins lifted cognitive scores slightly more than a self-guided version of the same habits. Both groups improved, and the extra benefit held for APOE4 gene carriers too.

Added Sep 25, 2026
Study
Structured vs Self-Guided Multidomain Lifestyle Interventions for Global Cognitive Function: The US POINTER Randomized Clinical Trial
Journal
JAMA, Aug 26, 2025 (Vol 334, Issue 8; online Jul 28, 2025)
Design
Randomized clinical trial, 2,111 adults at elevated risk of cognitive decline, 5 US sites, 2 years — structured vs self-guided program
Authors
Baker LD, Espeland MA, Whitmer RA, Snyder HM, Leng X, et al. (US POINTER Study Group)

How do you decide what's on this page?

How do you decide what's covered here, and how is it checked?
Every entry starts from a peer-reviewed paper found via PubMed — never a preprint, a press release, or a secondhand write-up. We check the paper's actual abstract and, where accessible, its full text directly, then write a plain-English headline and one-sentence summary of what the study found — not what a headline claimed. The evidence badge (large human study / human trial / review of existing research / animal study) tells you the study design at a glance, so you can judge the strength of the evidence yourself rather than take our word for it. Every entry links straight to the source (DOI and PubMed where available) so you can check it directly. Not medical advice — these are factual summaries, not a recommendation for what you should do. Compiled Sep 10, 2026.
Is anything on this page medical advice?
No. This page reports what a study found, in the study's own terms — it never interprets what a finding means for you personally, and never recommends a course of action. An animal study and a large human trial are reported with equally plain language but very different evidence badges, deliberately, so the difference is visible rather than smoothed over. Talk to your own doctor or another licensed health professional before acting on anything above.
How often is this page updated?
New studies are researched and added periodically, each one checked directly against the paper itself before publishing — not on a fixed schedule, and never auto-published without that check. The "last updated" date at the top of this page reflects when it was last refreshed.

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